Palmatine chloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

氯化巴马汀是一种异喹啉生物碱，是一种重要的药用草药提取物，具有多种药理和生物学特性。

Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.(In Vitro):Palmatine (0-100 μM; 42 h) suppresses WNV with an EC50 value of 3.6 μM, and reduce the viral titers of DENV-2 and YFV with EC50 values of 26.4 μM and 7.3 μM, respectively.Palmatine (0-1128 μM; 24-72 h) inhibits colon cancer cell proliferation.Palmatine (0-704 μM; 24 h) reduces AURKA protein levels, induces G2/M phase arrest, and induces apoptosis in colon cancer cells via the mitochondrial associated pathway.(In Vivo):Palmatine (50 or 100 mg/kg; p.o.; daily for 7 days) ameliorates DSS (dextran sulfate sodium)-induced colitis and prevents infiltration of inflammatory cells.Palmatine (0-200 mg/kg; i.p.; once) attenuates D-galactosamine/Lipopolysaccharides (HY-D1056)-induced fulminant hepatic failure in mice.Palmatine (0-1 mg/kg; i.p.; 10 days) shows memory-enhancing activity in mice.Palmatine (33.75-135 mg/kg; p.o.; daily for 26 days) can effectively inhibit the growth of HCT-116 xenografts in mice.

Palmatine (0-100 μM; 42 h) suppresses WNV with an EC50 value of 3.6 μM, and reduce the viral titers of DENV-2 and YFV with EC50 values of 26.4 μM and 7.3 μM, respectively.Palmatine (0-1128 μM; 24-72 h) inhibits colon cancer cell proliferation.?Palmatine (0-704 μM; 24 h) reduces AURKA protein levels, induces G2/M phase arrest, and induces apoptosis in colon cancer cells via the mitochondrial associated pathway. Cell Proliferation Assay Cell Line:HCT-116, SW480, HT-29 Concentration:0, 88, 176, 352, and 704 μM (HCT-116, SW480); 0, 141, 282, 564, and 1128 μM (HT-29)Incubation Time:24, 48 and 72 h Result:Decreased cell viability in a dose-dependent manner.Western Blot Analysis Cell Line:HCT-116, SW480, HT-29 Concentration:100 nM for HCT-116, 500 nM for SW480 and HT-29 Incubation Time:24 h Result:Promoted the expression of apoptosis markers such as P53 / P73, Caspase3, and Caspase9. Reduced AURKA protein levels. Increased cyt. c in the cytoplasm while reduced Bcl2 and Bcl-xl in a dose-dependent manner.Cell Cycle Analysis Cell Line:HCT-116, SW480 Concentration:88, 176, 352 and 704 μM Incubation Time:24 h Result:Induced G2/M phase arrest in a dose-dependent manner.Apoptosis AnalysisCell Line:HCT-116, SW480 Concentration:88, 176, 352 and 704 μM Incubation Time:24 h Result:Induced apoptosis in a dose-dependent manner.

Palmatine (50 or 100 mg/kg; p.o.; daily for 7 days) ameliorates DSS (dextran sulfate sodium)-induced colitis and prevents infiltration of inflammatory cells.?Palmatine (0-200 mg/kg; i.p.; once) attenuates D-galactosamine/Lipopolysaccharides (HY-D1056)-induced fulminant hepatic failure in mice.?Palmatine (0-1 mg/kg; i.p.; 10 days) shows memory-enhancing activity in mice.Palmatine (33.75-135 mg/kg; p.o.; daily for 26 days) can effectively inhibit the growth of HCT-116 xenografts in mice. Animal Model:DSS- induced Colitis BALB/c mice model (8-week-old)Dosage:50 or 100 mg/kg Administration:Orally, daily, for 7 days Result:Ameliorated DSS-induced colitis and prevented infiltration of inflammatory cells; remarkably extended the colon length; significantly suppressed the colonic MPO activity. Decreased the levels of colonic inflammatory cytokines (TNF-α, IFN-γ, IL-1β, IL-6, IL-4 and IL-10); Protected mucosal integrity by modulating TJs protein and apoptosis proteins; Restored DSS-induced decreases of TJ protein ZO-1, ZO-2 and claudin-1; Reduced Bax expression and enhanced Bcl-2 expression at the dose of 100?mg/kg, prevented epithelial apoptosis and improved intestinal integrity. Prevented DSS-induced changes of gut microbiota in colitis mice.Animal Model:Male ICR mice (20–22 g), D-galactosamine/lipopolysaccharide (GalN/LPS)-induced fulminant hepatic failure model Dosage:25, 50, 100, or 200 mg/kg Administration:Intraperitoneal injection, 1 h before the GalN/LPS treatment Result:Attenuated the mortality and serum aminotransferase activities increased by GalN/LPS. Prevented the increase of serum TNF-α and augmented that of serum IL-10. Decreased the TNF-a mRNA expression and increased the IL-10 mRNA expression. Attenuated the apoptosis of hepatocytes.Animal Model:Swiss young male albino mice, with Scopolamine (HY-N0296)- and diazepam-induced amnesia model Dosage:0.1, 0.5, 1 mg/kg Administration:Intraperitoneal injection, 10 days Result:Significantly improved learning and memory of mice at 0.5 and 1 mg/kg and did not show any significant effect on locomotor activity of the mice. Significantly reversed scopolamine- and diazepam-induced amnesia in mice. Significantly reduced brain acetylcholinesterase activity of mice.Animal Model:BALB/c-nude mice, HCT-116 xenograft model Dosage:33.75, 67.5 and 135 mg/kg Administration:Oral administration, once a day for 26 days Result:The tumor volume and weight of the treatment group were significantly reduced.

Palmatine chloride

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10605-02-4

387.87

C21H22ClNO4

>98% (HPLC)

Ethanol: 14 mg/mL warmed (36.09 mM); Water: 5 mg/mL (12.89 mM); DMSO: 77 mg/mL (198.52 mM)

COC1=C(OC)C2=C[N+](CCC3=C4C=C(OC)C(OC)=C3)=C4C=C2C=C1.[Cl-]

2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium chloride

(-20℃)

With Ice Pack

≥ 2 years